Nuestra Señora de la Encarnación, known as the Catedral Primada de América, is the oldest cathedral in the Americas, located in Santo Domingo's historic Zona Colonial. This significant UNESCO World Heritage site is generally accessible, though its historic architecture may present some challenges for full wheelchair access, with steps at entrances. Visitors can explore independently, often with an included audio guide, or as part of a broader guided tour of the Zona Colonial, which provides deeper historical context. The cathedral is open year-round, typically from morning to late afternoon on weekdays and Saturdays, with limited hours or closures on Sundays and major holidays for services; checking specific opening times is advisable. There is a small entrance fee, usually a few USD (e.g., 200-300 DOP), which often includes an audio guide. A typical visit lasts between 45 minutes to 1.5 hours. It is essential to dress modestly, covering shoulders and knees, out of respect for its religious significance. Photography is usually permitted without flash, but certain areas may have restrictions.